The Best Cannabis Strains for Depression

The Best Cannabis Strains for Depression

From intense relaxation to cerebral stimulation, cannabis has all kinds of perks for users. People often use cannabis to help with issues like chronic pain, inflammation, and stress. But another one of the most interesting benefits of cannabis is that it can help with depression. According to research, even a couple of hits of weed can help tame symptoms of anxiety and depression.

While all cannabis strains can help enhance your mood and curtail stress, some strains are better than others for tackling symptoms of depression. Ideally, you’ll want a strain that’s especially uplifting and motivating. Fortunately, whether you prefer indica, sativa, or hybrid strains, there are various great choices. Here are some of the best cannabis strains for depression.

1. Guava

Guava is easily one of the best cannabis strains for depression. The flavor alone is enough to put most users in a good mood – this Gelato phenotype offers a particularly sweet and fruity yet slightly gas-like taste that makes it a treat to smoke or vape. Of course, this sativa-dominant hybrid also offers an array of enjoyable effects.

From the first hit, Guava will fill you with happy, positive feelings. It can ward off negativity and indifference, making everything feel more exciting and fun instead. It’s a top choice for a wake-and-bake strain, so if you need something that’ll help you start the day in a good mood, you can’t go wrong with this loveable cannabis strain.

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2. Wedding Crashers

Wedding Crashers (or simply “Wedding Crasher”) is another exemplary strain of weed that’s known for inducing positive feelings. It’s a hybrid strain created by crossing Purple Punch and Wedding Cake – two strains known for their exquisite flavors and enjoyable effects. As such, it’s no surprise that Wedding Crashers is just as delicious as it is mentally uplifting.

As you smoke or vape Wedding Crashers, you’ll be wowed by its sweet vanilla and grape-like flavor. Soon enough, you’ll feel a wave of optimistic energy rushing through your brain. Instead of feeling stressed, anxious, or depressed, you’ll feel joyous and ready to take on the day. It can also help enhance your creativity and focus, making it great for creative tasks.

Gelato 41

3. Gelato 41

Want a strain that’ll make you feel like you’re digging into a tasty bowl of Gelato? If so, Gelato 41 is sure to impress you. As a cross between Sunset Sherbert and Thin Mint Cookies, it’s no surprise that this strain offers mouthwatering hits whether you choose to smoke or vape it. It’s also not surprising that it offers an exceptionally enjoyable high.

Gelato 41 will hit you hard with intensely relaxing effects. The physical effects can help you alleviate pain, inflammation, and stress. Meanwhile, it can also help calm your mind and relieve you of any anxiety or worries. Ultimately, you’ll find yourself in a blissful and carefree state that makes it hard to feel depressed about anything. With that said, this strain can be a little too powerful for some beginner users.

4. Big Head

Want a strain that can fill you with euphoria and bliss without feeling too overpowering? If so, you’ll want to try Big Head. This exotic strain is relatively rare and not much is known about it. However, many users find it especially relaxing and rewarding – especially if you’re looking to counteract symptoms of chronic stress and depression.

The euphoria-inducing effects of Big Head are ideal for melting away your stress and putting you in a happy, carefree state of mind. It can also soothe your body and help counteract chronic pain, inflammation, headaches, migraines, and other forms of physical distress. As such, this strain is worth trying for anyone.

5. Italian Ice

Italian Ice is another top cannabis strain that’s great for tackling depression. It likely gets its name from its outstanding appearance – Italian Ice is covered with frosty trichomes that make it look like it’s coated with ice. It also offers a tasty, dessert-like flavor with hints of sweet fruits and berries.

When you smoke or vape Italian Ice, you’ll be treated to a blissful and relaxing high. The physically relaxing effects will grow throughout your body, leaving you feeling light and tranquil. Meanwhile, the mental effects will help calm your mind and tackle symptoms of anxiety and depression.

Italian Ice

6. Do-Si-Dos

Also known as “Dosi Doe,” “Dosidos,” and “Dosi”, Do-Si-Dos is a well-known indica-dominant hybrid strain that offers a range of invigorating effects. Its bright green and lavender leaves give it tons of bag appeal while its earthy and floral aroma makes it a particularly alluring cannabis strain, but the high it offers is even better.

Do-Si-Dos is a hard-hitting strain that can instantly hit you with deep relaxation. Instead of feeling stressed or anxious, it can help you feel exceptionally relaxed and free of any worries. In addition to calming your mind, it’ll also soothe your entire body and relieve any kind of pain, aches, or tension.

7. Jealousy

While it might not sound like one of the best strains for depression, Jealousy is a surprisingly uplifting and enjoyable strain that’s sure to enhance your mood. This indica-dominant hybrid is a cross between Gelato 41 and Sherbert – two strains renowned for their great flavors and positive effects.

When you smoke or vape Jealousy, you’ll experience an invigorating wave of calming euphoria. Negative thoughts will be replaced by happiness, glee, and optimism. It also helps soothe your body, making it great for counteracting chronic pain, inflammation, or any other kind of physical distress.


If you’re looking for a cannabis strain to help counteract symptoms of depression and other mental health issues, these are seven of the best choices out there. Each of these strains can help enhance your mood and counteract stress and anxiety, putting you in a gleeful state of mind. Of course, these aren’t the only products that can help. Marijuana users in NY and DC can also explore a range of top-notch cannabis concentrates, edibles, vapes, and much more at Purple Penthouse.

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